| 1 | Santiago de Chile | Arrive international. Recover from jet lag — Bellavista, Cerro San Cristóbal or a wine-region day trip if you have a buffer. |
| 2 | Santiago → Coyhaique | Fly SCL → Balmaceda (3h 30min). Pick up 4×4. 50-minute drive to Coyhaique. 4×4 rental 3 months ahead; non-negotiable for some sections of the Carretera. Pick-up in Balmaceda, drop-off needs to be planned (see below). |
| 3 | Coyhaique base | Cerro Castillo National Park day trip (1h 15min south). Or full recovery day in Coyhaique. |
| 4 | Coyhaique → Puerto Río Tranquilo | 4-hour drive south on the Carretera Austral. Capillas de Mármol (Marble Caves) afternoon boat tour on Lago General Carrera. |
| 5 | Puerto Río Tranquilo → Caleta Tortel | 5–6 hour drive south, including ferry crossing at Puerto Yungay. Caleta Tortel is built entirely on cypress boardwalks over the water. |
| 6 | Caleta Tortel → Villa O'Higgins | 4-hour drive. Villa O'Higgins is the literal end of the Carretera Austral. Walk the Glaciar O'Higgins lookout if weather allows. |
| 7 | Villa O'Higgins → north | Long driving day back north along the Carretera. Overnight Cochrane or back at Puerto Río Tranquilo. Plan rental drop-off — Chile Chico is the realistic limit; cross-border drop-off into Argentina is rare and expensive. |
| 8 | Drive to Chile Chico | 3–4 hour drive on the south shore of Lago General Carrera (RN-265). Drop the rental in Chile Chico. |
| 9 | Cross border → Los Antiguos (AR) | Short land crossing at Chile Chico/Los Antiguos. SAG declaration before exiting Chile; Argentine immigration on the other side. New Argentine rental from Los Antiguos or Perito Moreno (small towns — book ahead). |
| 10 | Los Antiguos → Cueva de las Manos | 2–3 hour drive south to the Cueva de las Manos site (UNESCO World Heritage — 9,000-year-old hand stencils). Overnight in Bajo Caracoles. |
| 11 | Bajo Caracoles → El Chaltén | Long Ruta 40 drive south through the steppe — 7–9 hours. Spectacular emptiness, almost no services. Fuel up at every station; fill jerry cans for safety. |
| 12 | El Chaltén | Laguna de los Tres day hike — 22 km, the iconic Fitz Roy view. |
| 13 | El Chaltén | Laguna Torre or weather buffer. |
| 14 | El Chaltén → El Calafate | 3-hour drive south on Ruta 40. Drop the Argentine rental at FTE airport. |
| 15 | El Calafate | Perito Moreno glacier — full day on the catwalks. |
| 16 | El Calafate | Big Ice trek (USD 600–750) or Estancia Cristina full-day boat to Upsala glacier. Big Ice 2–3 months ahead in peak season. |
| 17 | El Calafate → Ushuaia | Fly FTE → USH (1h 15min). Internal flight FTE→USH is the bottleneck — book early, prices double 3 months out. |
| 18 | Ushuaia | Beagle Channel half-day catamaran (Les Eclaireurs lighthouse, sea lion island). Afternoon: Tierra del Fuego National Park. |
| 19 | Ushuaia | Maritime Museum (the original prison + Antarctic history) and a buffer day for weather. |
| 20 | Ushuaia → Buenos Aires | USH–AEP (3h 30min). Overnight in BA. Avoid same-day onward international connections. |
| 21 | Buenos Aires → home | International return. |